The Bulls have named Morne Steyn to win his 100th Super Rugby cap in a team that also features Wynand Olivier, Dewald Potgieter and Dean Greyling to play the Highlanders in Dunedin.
Olivier replaces Francois Venter and Potgieter comes in for injured Deon Stegmann from the side that beat the Waratahs in Sydney last week, having both been declared fit for the match.
Greyling returns to the side after he missed the Waratahs clash due to maternity leave and replace Dawie Steyn.
Potgieter joined the squad on Sunday after recovering from a hamstring strain and Olivier was rested against the Waratahs in order to recover from bruised ribs.
Bulls fly half Morne Steyn will become the sixth player from the Bulls to play 100 Super Rugby matches.
Bulls coach France Ludeke said he was pleased that Steyn would make the milestone.
"He is such a humble person and the ultimate team player. I know that he would prefer a win on the day as the best form of celebration for this fantastic achievement."
Ludeke has warned that as they will be playing for the first time at the Forsyth Barr Stadium and being log leaders the Highlanders will have no shortage of motivation to beat the Bulls.
"We worked hard to be on top of the log, but the reality is that teams will be coming harder at us than before. The Highlanders had two disappointing results in their last outings and will come out to knock us over, no doubt. "
"We have picked up good momentum from our Australian leg of our tour and can welcome back three experienced campaigners, so if we focus on our own game and play to our strengths, we will be competitive."
Bulls captain Pierre Spies said the Steyn milestone will spur on the rest of the team.
"We can only try and reward Morne in the best way possible and that is to beat the Highlanders and remain on top of the log. They are a difficult side to play and we have battled against them at home in the past, but we know what we can do if we execute well on the day."
Zane Kirchner Akona Ndungane , Johann Sadie, Wynand Olivier , Bjorn Basson , Morne Steyn , Francois Hougaard , Pierre Spies (c), CJ Stander, Dewald Potgieter , Juandre Kruger , Flip van der Merwe , Werner Kruger , Chiliboy Ralepelle , Dean Greyling .
Replacements: Willie Wepener, Rayno Gerber, Wilhelm Steenkamp , Arno Botha , Jano Vermaak , Louis Fouche , JJ Engelbrecht .